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Abbreviations Notes
Aggr. NK-L = Aggressive NK-Cell Leukemia
Angioimmunoblastic T-Cell Lymphoma
Adult T-Cell Leukemia / Lymphoma
= B-Cell Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma
BM = Bone Marrow
B-PLL = B-Cell Prolymphocytic Leukemia
Burkitt = Burkitt Lymphoma
CLPD-NK = Chronic Lymphoproliferative Disorders of NK Cells
DLBCL (NOS) = Diffuse Large B-Cell Lymphoma, not otherwise specified
EATL = Enteropathy-Associated T-Cell Lymphoma
FL = Follicular Lymphoma
HCD = Heavy Chain Diseases
HCL = Hairy Cell Leukemia
HSTL = Hepatosplenic T-Cell Lymphoma
KIR = Killer-cell Immunoglobulin-like Receptor
LPL = Lymphoplasmacytic Lymphoma
MALT-L = Mucosa-Associated Lymphoid Tissue Lymphoma
= Mantle Cell Lymphoma
MF = Mycosis Fungoides
NMZL = Nodal Marginal Zone Lymphoma
PCM = Plasma Cell Myeloma
PTCL (NOS) = Peripheral T-Cell Lymphoma, not otherwise specified
S├ƒ┬ęzary S = S├ƒ┬ęzary Syndrome
SMZL = Splenic Marginal Zone Lymphoma
SPTCL = Subcutaneous Panniculitis-Like T-Cell Lymphoma
T-LGL = T-Cell Large Granular Lymphocyte Leukemia
T-PLL = T-Cell Prolymphocytic Leukemia
Type II EATL = Type II Enteropathy-Associated T-Cell Lymphoma

(1) Waldenström macroglobulinema (9761/3) is found in a significant subset of patients with LPL with BM involvement and an IgM monoclonal gammopathy of any concentration.
(2) Typically IgM+, and less often IgA+ or IgG+.
(3) IgD is positive in a minority of the cases.
(4) IgM+/-, IgD, IgG or rarely IgA.
(5) More frequently with Lambda than Kappa restriction.
(6) The membrane expression of CD3 may be weak.
(7) 25% of patients coexpress CD8 with CD4, a feature
almost unique to T-PLL; 15% are CD4-neg, CD8-pos.
(8) Expression of CD94 and KIR families of receptors can be detected in 50% or more of cases.
(9) Uncommon variants include CD4 TCRαβ-pos cases and TCRγδ-pos cases; approximately 60% of the latter express CD8, the remainder are CD4/CD8 double negative.
(10) Abnormal uniform expression of CD8 can be seen.
(11) KIR-pos cases preferentially express activating receptor isoforms.
(12) If TCRαβ-pos, expect different immunophenotype for the rest of the markers.
(13) A CD4-pos/CD8-neg phenotype predominates in nodal cases. CD4/CD8 double positivity or double negativity is at times seen.


For Research Use Only. Not for use in diagnostic procedures